I would have to agree with those above. My experience with a Colt Defender, albeit brief because I sold it less than a year after purchasing it, was that they are more prone to jamming and altogether present a less-than-reliable platform for HD or PD.
I offer a third vote for the M&P45 if you’re dead set on carrying that caliber.
And from this list, the M&P 45. I recently sold off all but one of my 1911’s, my HK45 and a few other plastic fantastics to standardize my carry platform on the M&P family. The M&P 45 is phenomenal.
I’ve seen far too many choke at the range to even consider carrying one of them for my protection. There’s just no excuse for the shit that Para’s factory lets out the door.
I would suggest spending some time reading the 1911 forum and previous discussions about the 1911 in general we’ve had on this forum in the past. (Use the search function and the tacked handgun help reference) There is a wealth of information to be had to guide your next purchase decision. If you have questions after going through all of that I’m sure someone can answer them.