Unless you are Jeff Bezos, Elon Musk, etc your in home defense scenarios are likely to be no more than 5-10 yards max. End to end my house is 60'. Keeping a consistent zero between practice and HD ammo is superfluous. At that distance you should be able to shoot from the hip for vitals shots. Or keep practicing.
If you are talking defense outdoors on a 500+ acre ranch then consistent POI matters. Muzzle velocity and penetration also. But then why use a pistol length AR?
With a 10-30 round mag FBI level penetration indoors is irrelevant. Barrier blind ammo and deep penetration should be the opposite of your optimum choice.
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